Accompanied by an increase in type II collagen cartilage fibrils synthesis (sPIINP increase) and a decrease in its catabolism (sC2C decrease), without changes in non-collagenous cartilage metabolism (sCOMP, sC846, and sYKL-40). post-race ( r = 0.610, p = 0.009) and a negative correlation of sPIIANP with sCRP 48-h post-race ( r = −0.570, p = 0.017).Ĭonclusion: Marathon running is an exercise with high-energy demands (sCK and sLDH increase) that provokes a high and durable general inflammatory reaction (sCRP increase) and an immediately post-marathon mechanism to protect inflammation and cartilage (sHA increase). 48 h post-race ( r = 0.563, p = 0.019) and sPIINP with sCK pre-race vs. We found a positive association between sCK levels with sLDH pre-race ( r = 0.758, p < 0.0001), post-race ( r = 0.623, p = 0.008) and 48-h post-race ( r = 0.842, p < 0.0001) sHA with sCRP post-race vs. In contrast, means COMP, sCS846, sPIIANP, and median sYKL-40 were relatively stable. Medians CRP increased (ten-fold) after 48 h post-race ( p < 0.0001).
Results: Medians CK and sLDH levels increased (three-fold, two-fold) post-race ( p < 0.0001 p < 0.0001) and (six-fold, 1.2-fold) 48 h post-race ( p < 0.0001 p < 0.0001). Serum levels of hyaluronan (HA), cartilage oligomeric matrix protein (COMP), aggrecan chondroitin sulphate 846 (CS846), glycoprotein YKL-40, human procollagen II N-terminal propeptide (PIINP), human type IIA collagen N-propeptide (PIIANP), and collagen type II cleavage (C2C) were measured by sandwich enzyme-linked immune-sorbent assay (ELISA). Serum C reactive protein (CRP), creatin kinase (CK), and lactate dehydrogenase (LDH) were determined using an AU-5800 chemistry analyser. Objective: To determine the effect of marathon running on serum levels of inflammatory, high energy, and cartilage matrix biomarkers and to ascertain whether these biomarkers levels correlate.ĭesign: Blood samples from 17 Caucasian male recreational athletes at the Barcelona Marathon 2017 were collected at the baseline, immediately and 48 h post-race. 8Department of Cardiology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.7Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.6Departament of Medicine, Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.5Research Program, Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain.3Department of Electronic Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain.2Department of Surgery, Faculty of Medicine, Universitat Autònoma Barcelona, Bellaterra, Spain.1Department of Orthopedic Surgery and Traumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.Hernández-Hermoso 1,2 * † Lexa Nescolarde 3 † Emma Roca 4 Elena Revuelta-López 5 Jordi Ara 6,7 Antoni Bayes-Genis 5,6,8
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